Kolliphor hs 15. It is freely soluble in water, ethanol and isopropanol.

Kolliphor hs 15 The free polyethylene glycol can be determined by HPLC. 1. Composition: Kolliphor® HS 15 consists of polyglycol mono- and di-esters of 12-hydroxystearic acid (= lipophilic part) and of about 30% of free polyethylene glycol (= hydrophilic part). 2025 注意喚起語: 警告 危険有害性情報: H317 アレルギー性皮膚反応を起こすおそれ。 H402 水生生物に有害。 注意書き（安全対策）: P280 保護手袋を着用すること。 P261 粉じん又は煙の吸入を避けること。 Kolliphor HS 15 Revision date : 2022/10/31 Page: 1/10 Version: 6. In brief, 18mg of ARE and 285mg of Kolliphor HS 15 were placed in a 25ml round bottom flask, and 4ml of water was added. It can form Kolliphor® HS 15; CAS Number: 70142-34-6; Synonyms: Macrogol (15)-hidroxiestearato,Polietilenglicol (15)-hidroxiestearato,Solutol® HS 15,Ácido 12-hidroxiesteárico polioxietilado; find Sigma-Aldrich-42966 MSDS, related peer-reviewed papers, technical documents, similar products & more at Sigma-Aldrich. Produktidentifikator Kolliphor® HS 15 Kolliphor ® HS 15 is mainly used as a solubilizer in parenteral and oral formulations. INTRODUCTION Coenzyme Q10 (CoQ10) is a fat-soluble vitamin analog found in the cells of many organisms, especially the inner mitochondrial membrane (1). 01. HS 15, Macrogol (15)-hydroxystearate, Polyethylene glycol (15)-hydroxystearate, Polyoxyethylated 12-hydroxystearic acid, Solutol ® HS 15 Sign In to View Organizational & Contract Pricing Select a Size Kolliphor HS 15 Revision date : 2022/10/31 Page: 1/10 Version: 7. Kolliphor® HS 15 is a yellowish white paste at room temperature that becomes liquid at approx. 2 of 5 03_111149e-04 Kolliphor® HS 15 1. In eukaryote, it functions as a cofactor in the electron transport chain and serves as a mod-ulator of the transition pore (2). It is freely soluble in water, ethanol and isopropanol. 2002 Produkt: Kolliphor® HS 15 (ID Nr. 1 Aquatic Acute 3 Pour les classifications mentionnées dans cette section dont le texte est incomplet, se référer au texte intégral à la rubrique 16. It is preferred for in vitro screening and in vivo efficacy studies of compounds. Datum vorherige Version: 15. -----7e21b209a6 Content-Disposition: form-data; name="files"; filename="C:\Temp\313848_BASF_PS_Kolliphor_HS_15_OnePager_A4_AS. 4) were used as vehicles. Kolliphor® HS 15 and Kolliphor® ELP Nonionic surfactants for use in parenteral biologics formulations 2 Kolliphor® HS15 Water soluble, amphiphilic, and nonionic surfactant Critical micelle concentration of 0. Feb 25, 2019 · The physicochemical properties of Kolliphor® HS 15 as a solubilizer have been studied extensively. Sep 4, 2015 · To enhance the stability of coenzyme Q10 (CoQ10), Kolliphor® HS 15 (HS15) was employed as a carrier to build up a stable CoQ10-loaded micelle delivery system. Eur. Surfactants are an essential component of biologics formulations, as they stabilize protein therapeutics such as monoclonal antibodies and fusion Kolliphor® HS-15 Kolliphor® HS-15 is a non-ionic surfactant that appears as a white-yellow paste that melts at 30°C to form a clear liquid. “Macrogol 15 Hydroxystearate” and USP-NF “Polyoxyl 15 Hydroxystearate”. It has a low immunogenicity, high solubilizing power and is listed in the FDA IID. PDF" Content-Type: application/pdf %PDF Kolliphor® HS 15 meets the requirements of the current monograph of Ph. BASF maintains a DMF for Kolliphor® HS-15, and the Aug 19, 2020 · Aim: We aimed to construct human serum albumin-Kolliphor ® HS 15 nanoparticles (HSA-HS15 NPs) to overcome the limitations in targeted therapy for rheumatoid arthritis (RA) and enhance the safety of drug-loaded HSA NPs. com Kolliphor ® HS 15 is a potent non-ionic solubilizer and emulsifying agent, with low toxicity. 0 (30554050/SDS_GEN_DO/EN) 1. 30554050/SDS_GEN_00/FR) date d'impression 27. Regulatory Documentation US-DMF #9501 (Type IV DMF, containing CMC information) Regulatory Information File (RIF) with equivalent content to an Open Part/ Applicants Part of a DMF See full list on americanpharmaceuticalreview. 2025 ABSCHNITT 1: Bezeichnung des Stoffes bzw. performance of the surfactants Polyoxyl 15 Hydroxystearate (Kolliphor® HS 15) and Polyoxyl-35-castor oil (Kolliphor® ELP) in stabilizing proteins formulations (Table 1). 02% Hydrophilic lipophilic balance of 15 Kolliphor® ELP Water soluble, amphiphilic, and nonionic surfactant Kolliphor ® HS 15 A nonionic solubilizer with low toxicity for parenteral applications View product Kolliphor ® P 188 Bio Designed to meet your needs in quality Produit: Kolliphor® HS 15 (ID Nr. 0 (30554050/SDS_GEN_US/EN) 1. Download the Kolliphor® HS 15 Case Study White Paper. The optimal preparation conditions were 1:6, 4 Preparation of Kolliphor H S 15-ARE micelles The new Kolliphor HS 15-ARE micelles were prepared with ARE and Kolliphor HS 15 at a mass ratio of 1:16 by dissolution method. Kolliphor ® HS 15 is also used in ophthalmic, macromolecule, suppository, and protein formulations due to its solubilization characteristics and safety profiles. Ideal for solubilizing low-solubility actives in microemulsions, it helps tackle even the toughest solubilization challenges. Kolliphor HS 15 is a nonionic solubilizer with low toxicity for parenteral applications. I agree that BASF Corporation and its affiliated companies (“BASF”) can contact me via email for the purpose of informing me about BASF products, services and events which BASF considers relevant for me and conducting customer surveys. des Gemisches und des Unternehmens 1. Description ®Kolliphor HS 15 is a yellowish white paste at room temperature that becomes liquid at approx. 30 °C. 7 With its profound safety and toxicological profile relatively better than polysorbate 80 and/or Kolliphor® EL, it is an excellent choice for screening and pre-clinical pharmacokinetic studies of cytotoxic and oncology drugs among many other indications. This study aimed to develop a new ARE injection using Kolliphor HS 15 as solubilizing … 30% (w/v) Kolliphor ® HS 15 (Solutol HS ® 15) and sodium phosphate buffer (0. 11. 0 (30554050/SDS_GEN_MX/EN) 1. Kolliphor HS 15 Revision date : 2022/10/31 Page: 1/9 Version: 4. The impact of micellar compositions, the preparation condition, and the preparation method on size characteristics, the solubilization efficiency, and micellar stability were investigated. Identification Product identifier used on the label Kolliphor HS 15 Recommended use of the chemical and restriction on use Recommended use*: pharmaceutical excipient Unsuitable for use: Not intended for sale to or use by the general public. 2025 Skin Sens. Kolliphor® HS-15 is endotoxin-controlled and packaged in steel with polyethylene in-liners. 2019 Vorherige Version: 4. 01 M, pH 7. Introduction ®Kolliphor HS 15 is a nonionic solubilizer and emulsifying agent obtained by reacting 15 moles of ethylene oxide with 1 mole of 12-hydroxy stearic acid. Polímero del ácido 12-hidroxi-octadecanoico con α-hidro-ω-hidroxipoli(oxi-1,2-etanediil); CAS Number: 70142-34-6; Synonyms: HS 15,Macrogol (15)-hidroxiestearato,Polietilenglicol (15)-hidroxiestearato,Solutol® HS 15,Ácido 12-hidroxiesteárico polioxietilado at Sigma-Aldrich 10; Kolliphor® HS 15; micelles; preparation; stability. It is a yellowish white paste that becomes a liquid at 30 °C and dissolves in water, ethanol and 2-propanol. 製品: Kolliphor® HS 15 (30554050/SDS_GEN_JP/JA) 印刷日: 23. Objective: This study found that the surfactant Kolliphor® HS 15 (HS 15) and SBECD had significant synergistic effects on solubilizing voriconazole, and a novel voriconazole complex delivery system (VRC-CD/HS 15) was established. A smooth glass mortar and pestle was used to triturate the Kolliphor ® HS 15 and SNAP 37889 into a paste before addition to the sodium phosphate buffer at room temperature (RT). 0 Datum / Erste Version: 12. The mixture was then stirred Polímero del ácido 12-hidroxi-octadecanoico con α-hidro-ω-hidroxipoli(oxi-1,2-etanediil); CAS Number: 70142-34-6; Synonyms: HS 15,Macrogol (15)-hidroxiestearato,Polietilenglicol (15)-hidroxiestearato,Solutol® HS 15,Ácido 12-hidroxiesteárico polioxietilado at Sigma-Aldrich A recently developed non-ionic surfactant called Solutol HS 15 (poly-oxyethylene esters of 12-hydroxystearic acid), with low toxicity in vivo, was shown to reverse completely the multidrug resistance of KB 8-5 and KB 8-5-11 human epidermoid carcinoma cells in vitro but Feb 25, 2019 · The physicochemical properties of Kolliphor® HS 15 as a solubilizer have been studied extensively. 30554050/SDS_GEN_DE/DE) Druckdatum 26. 04. Kolliphor® HS 15 is a nonionic solubilizer and emulsifying agent for parenteral and ophthalmic drugs. Éléments d'étiquetage Globally Harmonized System (GHS) / Système Général Harmonisé (SGH) Oct 14, 2021 · Kolliphor(R) HS 15 | C47H94O19 | CID 71311956 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological The commercially available alpha-asarone injections (CA-ARE) were frequently found to cause severe anaphylactic reactions by the solubilizer contained in the formulation such as polysorbate 80 and propylene glycol. nowru svbjoi lupfvwh dqzk ehqwfb pfjb mipg fgrr nev mdxxo